Nobel Prize in Medicine Awarded for In Vitro Fertilization

http://news.nationalgeographic.com/news/2010/10/101004-nobel-prize-medicine-ivf-science-health/

Nobel Prize in Medicine Awarded for In Vitro Fertilization
U.K. scientist Robert G. Edwards pioneered "test-tube baby" technique
Kate Ravilious in York, United Kingdom
National Geographic News
October 4, 2010

The 2010 Nobel Prize in Physiology or Medicine has been awarded to Robert G. Edwards, an 85-year-old British scientist who pioneered the fertility treatment in vitro fertilization.

Today nearly four million people have been born thanks to in vitro fertilization, which occurs when sperm is injected into an egg cell outside the body and the resulting embryo is implanted back into the womb.

Edwards first envisioned IVF during the 1950s and went on to develop and hone the technique in the 1960s and '70s.

He achieved his first success on July 25, 1978, when Louise Edwards, the world's first "test-tube baby" was born in the United Kingdom. Louise is unrelated to the scientist.

"This is a wonderful achievement and a great testimony to Edwards's pioneering work in reproductive science," said Richard Kennedy, a fertility expert at University Hospital in Coventry, U.K., and secretary general of the International Federation of Fertility Societies.

"The development of IVF has enabled many millions of couples to have a child who might not otherwise have been able to," he said in a telephone interview.

The Nobel Assembly at Sweden's Karolinska Institute, which awarded the 10-million-Swedish-krona (1.5 million-U.S.-dollar) prize, described IVF as a "milestone of modern medicine, which brings joy to infertile people all over the world."

Robert Edwards was too ill to speak to the media about his award, Nobel committee member Goran Hansson told a news conference in Stockholm Monday.

But, Hansson added, "I spoke to his wife, and she was delighted. She was sure he would also be delighted."

Birth of a Nobel-Worthy Technique

More than 10 percent of couples worldwide are infertile. In the past medical help was limited, but today IVF therapy results in successful births for roughly one in five of every fertilized egg implanted.

The odds for a healthy couple conceiving naturally are about the same.

Edwards's initial inspiration came from the work of other scientists, which showed that egg cells from rabbits could be fertilized in test tubes when sperm was added.

The scientist realized that this could be a potential treatment for human infertility and began to experiment with human egg cells.

Along with colleagues, Edwards clarified how human eggs mature, how different hormones regulate their maturation, and at what point the eggs are ready to be fertilized.

In 1969, while at the University of Cambridge, Edwards and his team managed to fertilize a human egg in a test tube for the first time.

However, this fertilized egg didn't develop beyond single cell division, so Edwards suspected that he needed to use eggs that had matured in the ovaries before removal for IVF.

Working with gynecologist Patrick Steptoe, he safely extracted matured eggs from ovaries, using laparoscopy—an optical technique developed by Steptoe—to look at eggs in the ovaries.

This time the pair were able to fertilize an egg and get it to divide several times, though the embryo stopped growing at only eight cells.

In Vitro Fertilization "Here to Stay"

At this point controversy erupted, with opposition to the technique coming from religious leaders and various governments. The U.K.'s Medical Research Council decided not to continue funding the project.

However, a private donation enabled the pair to continue their research, which ultimately led to their first complete success—Louise Edwards's birth.

Since 1978 the technique has been further refined, resulting in easier and more comfortable methods of egg removal.

However, in vitro fertilization treatments often lead to multiple pregnancies, which can pose risks to both the babies and the mother. For instance, multiple pregnancies can increase the likelihood for premature delivery and low birth weight, according to the University of Maryland Medical Center.

Even so, "IVF is here to stay," said University Hospital's Kennedy.

"I expect it will be combined with genetic screening in the future, to lessen the likelihood of inherited diseases, and there will be refinements to improve the success rates and reduce the chances of multiple births."